ALT and AST — Liver Enzymes — 60-Second Protocol
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lab guide · 2026-09-11
A mildly raised liver enzyme is the most common early signal of fatty liver.
Alanine and aspartate transaminases leak into blood when liver cells are stressed. Mild persistent elevations are the most common signal of fatty liver disease. AST/ALT > 2 with alcohol exposure suggests alcohol-related injury.
The protocol
| Units | U/L |
| Standard range | ALT 7–55; AST 8–48 (varies by lab) |
| Optimal range | ALT 7–20; AST 8–25 |
| 2-5x | clinician follow-up |
| ≥5x | urgent referral |
| normal | no action |
| mild elevation 1–2x | investigate fatty liver, weight, alcohol |
| Diet | reduce alcohol, refined carbs, ultrasugar |
| Weight | 5–10% loss often normalises ALT |
| Testing | recheck in 3 months after lifestyle change |
| Movement | daily Zone 2 cardio |
Full transcript
A mildly raised liver enzyme is the most common early signal of fatty liver. ALT and AST leak into the blood when liver cells are stressed. Optimal is ALT seven to twenty and AST eight to twenty-five, while the standard reference runs much wider. A mild elevation, one to two times the range, is where you look at weight, alcohol and fatty liver. Two to five times means clinician follow-up, and five times or more is an urgent referral. Less alcohol, fewer refined carbs, daily zone two, and a five to ten percent weight loss often normalises ALT. agegen.ai. Generate your prime age! ~~ Mr. Age
Sources
- https://medlineplus.gov/lab-tests/liver-function-tests/
- https://www.niddk.nih.gov/health-information/liver-disease
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